Kynurenine Metabolism Mediates Tumor Progression in Renal Cell Carcinoma
Kayla M. Miller, Skye P. Rounseville, Raúl Castro-Portuguez, Robert Railey, Hope T. L. Dang, Kailyn Dundore, Luis S. Espejo, Samuel Freitas, George L. Sutphin
This study investigates the role of kynurenine pathway enzymes in renal cell carcinoma progression using CRISPR/Cas9 knockouts, showing distinct effects on tumor behavior in vitro and in vivo.
bioRxiv · Feb 14, 2026 · PreprintCancer Biology