Author

Hope T. L. Dang

University of Arizona

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Approach:genetic perturbation / CRISPR· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1

Frequent Co-Authors

George L. SutphiniD· 3 shared Luis S. EspejoiD· 3 shared Raúl Castro-PortugueziD· 3 shared Samuel FreitasiD· 3 shared Jeremy Meyers· 2 shared Alana M. Hendrickson· 1 shared Bradford HulliD· 1 shared Caroline CorbaniD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersMolecular Biology

George L. SutphinORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

ATG-9-Induced Lysosomal Membrane Permeabilization and Cell Death in a Caenorhabditis elegans model of Mucolipidosis type IV

Hope T. L. Dang, Teresa Horm, Savannah Perno, Shirine Gholam, Marvin O’Ketch, Shaharyar Ashraf, Sebastian Hernandez, Justin Randall, Hanna Fares

This study identifies ATG-9-mediated lysosomal membrane permeabilization as a mechanism of cell death in a C. elegans model of Mucolipidosis type IV.

bioRxiv · Jul 7, 2026 · PreprintCell Biology

Kynurenine Metabolism Mediates Tumor Progression in Renal Cell Carcinoma

Kayla M. Miller, Skye P. Rounseville, Raúl Castro-Portuguez, Robert Railey, Hope T. L. Dang, Kailyn Dundore, Luis S. Espejo, Samuel Freitas, George L. Sutphin

This study investigates the role of kynurenine pathway enzymes in renal cell carcinoma progression using CRISPR/Cas9 knockouts, showing distinct effects on tumor behavior in vitro and in vivo.

bioRxiv · Feb 14, 2026 · PreprintCancer Biology

Inhibition of haao-1 enhances oxidative stress response by activating hormetic redox signaling in C. elegans.

Raúl Castro-Portuguez, Kayla M. Raymond, Emma Thullen, Alana M. Hendrickson, Samuel Freitas, Bradford Hull, Jeremy Meyers, Niall Thorns, Emily A. Gardea, Hope T. L. Dang, Luis S. Espejo, George L. Sutphin

The paper shows that inhibiting haao-1 in C. elegans enhances oxidative stress resistance by activating the Nrf2/SKN-1 pathway through a hormetic redox mechanism.

bioRxiv · Feb 16, 2023 · PreprintMolecular Biology

3-hydroxyanthranilic acid - a new metabolite for healthy lifespan extension

Hope T. L. Dang, Raúl Castro-Portuguez, Luis S. Espejo, Grant Backer, Samuel Freitas, Erica Spence, Jeremy Meyers, Karissa Shuck, Caroline Corban, Teresa Liu, Shannon Bean, Susan Sheehan, Ron Korstanje, George L. Sutphin

This study identifies 3-hydroxyanthranilic acid (3HAA) as a metabolite that extends lifespan and improves health in C. elegans and mice by reducing oxidative stress and activating the Nrf2/SKN-1 pathway.

bioRxiv · Jun 1, 2021 · PreprintMolecular Biology