Author

Samuel Freitas

University of ArizonaORCID 0000-0002-9129-4715Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:C. elegans· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

George L. SutphiniD· 3 shared Hope T. L. Dang· 3 shared Luis S. EspejoiD· 3 shared Raúl Castro-PortugueziD· 3 shared Jeremy Meyers· 2 shared Alana M. Hendrickson· 1 shared Bradford HulliD· 1 shared Caroline CorbaniD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersMolecular Biology

George L. SutphinORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Kynurenine Metabolism Mediates Tumor Progression in Renal Cell Carcinoma

Kayla M. Miller, Skye P. Rounseville, Raúl Castro-Portuguez, Robert Railey, Hope T. L. Dang, Kailyn Dundore, Luis S. Espejo, Samuel Freitas, George L. Sutphin

This study investigates the role of kynurenine pathway enzymes in renal cell carcinoma progression using CRISPR/Cas9 knockouts, showing distinct effects on tumor behavior in vitro and in vivo.

bioRxiv · Feb 14, 2026 · PreprintCancer Biology

Inhibition of haao-1 enhances oxidative stress response by activating hormetic redox signaling in C. elegans.

Raúl Castro-Portuguez, Kayla M. Raymond, Emma Thullen, Alana M. Hendrickson, Samuel Freitas, Bradford Hull, Jeremy Meyers, Niall Thorns, Emily A. Gardea, Hope T. L. Dang, Luis S. Espejo, George L. Sutphin

The paper shows that inhibiting haao-1 in C. elegans enhances oxidative stress resistance by activating the Nrf2/SKN-1 pathway through a hormetic redox mechanism.

bioRxiv · Feb 16, 2023 · PreprintMolecular Biology

3-hydroxyanthranilic acid - a new metabolite for healthy lifespan extension

Hope T. L. Dang, Raúl Castro-Portuguez, Luis S. Espejo, Grant Backer, Samuel Freitas, Erica Spence, Jeremy Meyers, Karissa Shuck, Caroline Corban, Teresa Liu, Shannon Bean, Susan Sheehan, Ron Korstanje, George L. Sutphin

This study identifies 3-hydroxyanthranilic acid (3HAA) as a metabolite that extends lifespan and improves health in C. elegans and mice by reducing oxidative stress and activating the Nrf2/SKN-1 pathway.

bioRxiv · Jun 1, 2021 · PreprintMolecular Biology