Luis S. Espejo

This study investigates the role of kynurenine pathway enzymes in renal cell carcinoma progression using CRISPR/Cas9 knockouts, showing distinct effects on tumor behavior in vitro and in vivo.

This paper investigates how 3HAA and haao-1 inhibition affect C. elegans immune function and aging, finding that 3HAA improves immune function and acts as an antimicrobial against gram-negative bacteria.

The paper shows that inhibiting haao-1 in C. elegans enhances oxidative stress resistance by activating the Nrf2/SKN-1 pathway through a hormetic redox mechanism.

This study identifies 3-hydroxyanthranilic acid (3HAA) as a metabolite that extends lifespan and improves health in C. elegans and mice by reducing oxidative stress and activating the Nrf2/SKN-1 pathway.