George L. Sutphin

This study investigates the role of kynurenine pathway enzymes in renal cell carcinoma progression using CRISPR/Cas9 knockouts, showing distinct effects on tumor behavior in vitro and in vivo.

This study identifies experimental variables affecting stress response outcomes in C. elegans aging research and proposes standardized guidelines to improve reproducibility.

This paper investigates how 3HAA and haao-1 inhibition affect C. elegans immune function and aging, finding that 3HAA improves immune function and acts as an antimicrobial against gram-negative bacteria.

The paper shows that inhibiting haao-1 in C. elegans enhances oxidative stress resistance by activating the Nrf2/SKN-1 pathway through a hormetic redox mechanism.

This study identifies 3-hydroxyanthranilic acid (3HAA) as a metabolite that extends lifespan and improves health in C. elegans and mice by reducing oxidative stress and activating the Nrf2/SKN-1 pathway.

The paper integrates heterogeneous functional genomics data across species to identify genes and pathways underlying aging, finding Cd63 as a key gene with lifespan-extending effects in C. elegans.