Multi-region biopsies and patient-derived neurosphere cultures reveal spatial divergence in glioblastoma.
Roberto Salatino, Jacob Geisberg, Arantxa Romero-Toledo, Benjamin Oakes, Jerome C. Nwachukwu, Dobeen Hwang, Cristina Vincentelli, Oszkar Szentirmai, Thomas O. McDonald, K.W. Nettles, Franziska Michor A, Michalina Janiszewska
This study shows that multi-region neurospheres from glioblastoma tumors retain spatial diversity and drug response patterns linked to their original biopsies, highlighting their importance for modeling intratumor heterogeneity.
bioRxiv · Apr 10, 2026 · PreprintCancer Biology