Michalina Janiszewska

Photoproximity labeling of c-Myc reveals SLK as a cancer specific co-regulator

The paper identifies SLK as a cancer-specific co-regulator of c-Myc using photoproximity labeling, showing it stabilizes c-Myc and drives tumorigenesis through splicing changes.

Multi-region biopsies and patient-derived neurosphere cultures reveal spatial divergence in glioblastoma.

This study shows that multi-region neurospheres from glioblastoma tumors retain spatial diversity and drug response patterns linked to their original biopsies, highlighting their importance for modeling intratumor heterogeneity.

Selective Glucocorticoid Receptor Modulators of Immune Checkpoint Function

The paper develops selective glucocorticoid receptor modulators (SGRMs) that modulate immune checkpoint function by altering GR activity states through structural design and machine learning.

Structural insights into IMP2 dimerization and RNA binding

This study determines the structural properties of full-length IMP2, revealing its dimeric conformation and RNA-induced changes, which may inform drug design.

Cell sorting based on single nucleotide variation enables characterization of mutation-dependent transcriptome and chromatin states.

The paper develops STAR-FACS to sort cells by SNVs and shows distinct transcriptomes in glioblastoma cells with different TERT promoter mutations.