Weaning imprints a hybrid cytotoxic-regulatory identity on intestinal CD4+ T lymphocytes
Marina Schernthanner, Rohit Gokhale, Alexandra Thoms, Gabriella Lima dos Reis, Marwa Saad, Mackenzie Marie Clark, Yue S. Yin, Izabela Mamede, Bernardo Sgarbi Reis, Tiago B. R. Castro, Roham Parsa, Elaine V. Fuchs, Daniel Mucida, Angelina Morand Bianchi Bilate
This study tracks intestinal CD4+ T cells from suckling to adulthood, showing they adopt a transient cytotoxic-regulatory state at weaning, influenced by microbiota and early-life commensals.
bioRxiv · Oct 27, 2026 · PreprintImmunology