Daniel Mucida

This study tracks intestinal CD4+ T cells from suckling to adulthood, showing they adopt a transient cytotoxic-regulatory state at weaning, influenced by microbiota and early-life commensals.

This study shows that colorectal cancers with different metastatic potential trigger distinct early T cell responses, with non-metastatic tumors inducing cytotoxic T cells and pro-metastatic tumors causing hypoactivated T cells.

The paper tests a new peer-review model that separates scientific quality from impact, showing reviewers can effectively evaluate both dimensions and participants support its adoption.

This study shows eosinophils mediate protective intestinal remodeling in food allergies by interacting with epithelial cells, and their depletion worsens symptoms.

This study uses TRACK mice to show tissue-specific clonal selection and differentiation of CD4+ T cells during influenza infection, revealing organ-specific transcriptional programs and memory formation patterns.

The paper shows how immune cells adapt to different stem cell niches in skin to maintain tissue homeostasis by adjusting their functions based on the niche's specific demands.

The paper identifies distinct cDC2 subpopulations that direct microbiota-specific T cell differentiation through varied interactions.

This study shows that endogenous retroelements promote tolerance to dietary antigens by regulating regulatory T cell function and dendritic cell activity through innate sensing pathways.

The paper identifies gut bacteria-derived succinate as a key metabolite that promotes enteric nervous system regeneration after antibiotic-induced dysbiosis.

The paper shows that histone butyrylation in intestinal epithelial cells is regulated by microbiota and the metabolite tributyrin, and is linked to gene expression.

The paper shows that gut microbes influence sympathetic neurons through a metabolite-mediated gut-brain circuit, with butyrate suppressing sympathetic activity.

The paper identifies a microbiota-influenced subset of enteric neurons that regulate glucose levels through insulin signaling.