Angelina Morand Bianchi Bilate

Weaning imprints a hybrid cytotoxic-regulatory identity on intestinal CD4+ T lymphocytes

This study tracks intestinal CD4+ T cells from suckling to adulthood, showing they adopt a transient cytotoxic-regulatory state at weaning, influenced by microbiota and early-life commensals.

Colorectal cancers with distinct metastatic potential trigger divergent early T cell responses

This study shows that colorectal cancers with different metastatic potential trigger distinct early T cell responses, with non-metastatic tumors inducing cytotoxic T cells and pro-metastatic tumors causing hypoactivated T cells.

Tissue-specific clonal selection and differentiation of CD4+ T cells during infection

This study uses TRACK mice to show tissue-specific clonal selection and differentiation of CD4+ T cells during influenza infection, revealing organ-specific transcriptional programs and memory formation patterns.

One-step generation of TCR knock-in mice targeted to the TCRβ locus results in functional mature T lymphocytes

This paper develops a method to generate TCR knock-in mice with functional T cells by integrating TCRβ sequences into the Trb locus using AAV and CRISPR/Cas9, overcoming limitations of traditional transgenic models.

Deletion of the AMPylase mFICD alters cytokine secretion and affects cognitive plasticity in vivo

This study shows that deleting mFICD in mice affects cytokine secretion and improves cognitive plasticity in older mice.