Yue S. Yin

Weaning imprints a hybrid cytotoxic-regulatory identity on intestinal CD4+ T lymphocytes

This study tracks intestinal CD4+ T cells from suckling to adulthood, showing they adopt a transient cytotoxic-regulatory state at weaning, influenced by microbiota and early-life commensals.

Colorectal cancers with distinct metastatic potential trigger divergent early T cell responses

This study shows that colorectal cancers with different metastatic potential trigger distinct early T cell responses, with non-metastatic tumors inducing cytotoxic T cells and pro-metastatic tumors causing hypoactivated T cells.

Urea is a dynamic and functional component of mammalian breast milk

This study shows milk urea increases during lactation, is conserved across mammals, and supports infant gut microbiome establishment through urea-metabolizing bacteria.

Gut microbiota phospholipids regulate intestinal gene expression and can counteract the effects of antibiotic treatment

The paper identifies microbially-produced phospholipids that reduce inflammation and counteract antibiotic-induced type 1 diabetes in mice, with similar effects observed in humans.