Elaine V. Fuchs

This study identifies a microbial-immune-epithelial feedback mechanism that regulates stem cell activity and skin barrier function through prostaglandin E2 signaling.

This study tracks intestinal CD4+ T cells from suckling to adulthood, showing they adopt a transient cytotoxic-regulatory state at weaning, influenced by microbiota and early-life commensals.

The paper shows E-cadherin redistribution creates tension heterogeneity, triggering cell competition that eliminates pre-malignant cells, but this system can fail, leading to tumor susceptibility.

The paper shows how immune cells adapt to different stem cell niches in skin to maintain tissue homeostasis by adjusting their functions based on the niche's specific demands.

The paper introduces NEPTUNE, an in utero nanoinjection method to study gene function in mouse embryos, and shows that Sptbn2 silencing causes neural tube defects and embryo resorption.