A commensally regulated immune rheostat fine-tunes skin barrier fitness
Anita Gola, Rohith Srinivas, Elias G. Rodig, Marina Schernthanner, Merve Deniz Abdusselamoglu, Matthew Timothy Tierney, Natalie J. Alexander, Kevin Andrew Uy Gonzales, Sairaj M. Sajjath, Luis F. Soto-Ugaldi, Alain R. Bonny, Elaine V. Fuchs
This study identifies a microbial-immune-epithelial feedback mechanism that regulates stem cell activity and skin barrier function through prostaglandin E2 signaling.
Science · Oct 29, 2026Peer-reviewedImmunology