Sairaj M. Sajjath

This study identifies a microbial-immune-epithelial feedback mechanism that regulates stem cell activity and skin barrier function through prostaglandin E2 signaling.

The paper shows E-cadherin redistribution creates tension heterogeneity, triggering cell competition that eliminates pre-malignant cells, but this system can fail, leading to tumor susceptibility.

The paper uses mtDNA mutations to trace clonal relationships of innate immune cells in cancer, showing myeloid clones are linked to monocytes and have distinct epigenetic profiles.

The paper shows how immune cells adapt to different stem cell niches in skin to maintain tissue homeostasis by adjusting their functions based on the niche's specific demands.