Author

Yan Coulombe

Hôpital de l'Enfant-Jésus

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Assay:proteomics· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Jean‐Yves MassoniD· 2 shared Anja‐Katrin BielinskyiD· 1 shared Aruna ArumugamiD· 1 shared Carolina A. Novoa· 1 shared Christelle Keong· 1 shared Emily Yun-Chia Chang· 1 shared Franciele Faccio BusattoiD· 1 shared Jean-Yves Masson· 1 shared

Activity by Year

2017-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersMolecular Biology

Jean‐Yves MassonORCID

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3 papers

Recent·Most cited

The Ski2 helicase ASCC3 unwinds DNA upon fork stalling to control replication stress responses

Shixin Cui, Nicole L. Batenburg, Yan Coulombe, Aruna Arumugam, John R. Walker, Sadaf Valeh Sheida, Anja‐Katrin Bielinsky, M.C. Wahl, Jean‐Yves Masson, Xu‐Dong Zhu

This study identifies ASCC3 as a helicase that unwinds DNA at stalled replication forks, promoting fork reversal and preventing genomic instability during replication stress.

bioRxiv · Jul 24, 2025 · PreprintMolecular Biology

Arginine methylation of DDX5 RGG/RG motif by PRMT5 regulates RNA/DNA resolution.

Sofiane Yacine Mersaoui, Zhenbao Yu, Yan Coulombe, Martin Karam, Franciele Faccio Busatto, Jean‐Yves Masson, Stéphane Richard

The paper identifies DDX5 as an RNA helicase involved in R-loop resolution, showing that PRMT5-mediated arginine methylation of DDX5's RGG/RG motif regulates its interaction with XRN2 and R-loop degradation.

The EMBO Journal · Jun 21, 2019Peer-reviewedMolecular Biology

Conserved roles of RECQ-like helicases Sgs1 and BLM in preventing R-loop induced genome instability

Carolina A. Novoa, Emily Yun-Chia Chang, Maria J. Aristizabal, Yan Coulombe, Romulo Segovia, Yaoqing Shen, Christelle Keong, Steven J.M. Jones, Jean-Yves Masson, Michael S. Kobor, Peter C. Stirling

This study shows Sgs1 and BLM helicases prevent R-loop induced genome instability in yeast and human cells by reducing R-loop accumulation and mitigating replication-transcription collisions.

bioRxiv · Mar 23, 2017 · PreprintCell Biology