OST Catalytic Subunit Redundancy Enables Therapeutic Targeting of N-Glycosylation
Marta Baro, Hojin Lee, Vanessa M. Kelley, Rongliang Lou, Chatchai Phoomak, Katerina A. Politi, Caroline J. Zeiss, Michael C. Van Zandt, Joseph N. Contessa
The paper develops OST inhibitors that selectively target STT3A and STT3B, leading to tumor regression in EGFR-mutant lung cancer models.
Cell chemical biology · Dec 5, 2024Peer-reviewedCancer Biology