Intracellular crowding links dimensionality to cell fate through a mechano-metabolic signalling axis
Marieke Meteling, Bas van Loo, Ceri‐Anne E. Suurmond, Rick Mulders, Roos Wijngaarden, Kannan Govindaraj, Liesbet Geris, I. Meulenbelt, Y.F. Ramos, Liliana Moreira Teixeira, Jeroen Leijten
This study shows that cell culture dimensionality affects intracellular crowding, which influences cell fate through a mechano-metabolic signaling pathway, improving chondrogenic differentiation in microtissue cultures.
bioRxiv · Jan 22, 2026 · PreprintCell Biology