Intracellular crowding links dimensionality to cell fate through a mechano-metabolic signalling axis
Marieke Meteling, Bas van Loo, Ceri‐Anne E. Suurmond…·Jeroen Leijten
This study shows that cell culture dimensionality affects intracellular crowding, which influences cell fate through a mechano-metabolic signaling pathway, improving chondrogenic differentiation in microtissue cultures.