The ChAHP chromatin remodelling complex regulates neurodevelopmental disorder risk genes to scale the production of neocortical layers
Samuel Clémot-Dupont, José Alex Lourenço Fernandes, Sarah Larrigan, Xiaoqi Sun, Suma Medisetti, Rory Stanley, Ziyad El Hankouri, Shrilaxmi V. Joshi, David J. Picketts, Karthik Shekhar, Pierre A. Mattar
The paper shows that the ChAHP complex regulates upper-layer neuron production and NDD risk genes during neocortical development through progenitor proliferation and gene regulation.
Proceedings of the National Academy of Sciences · Jan 14, 2025Peer-reviewedNeuroscience