Author

Sarah Larrigan

University of Ottawa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Pierre A. MattariD· 3 shared David J. PickettsiD· 2 shared Shrilaxmi V. JoshiiD· 2 shared Iris LaskeriD· 1 shared José Alex Lourenço FernandesiD· 1 shared Karthik ShekhariD· 1 shared Lina Alegria Dizon-Mapula· 1 shared Rory Stanley· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersNeuroscience

Pierre A. MattarORCID

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3 papers

Recent·Most cited

An allelic series reveals the genetic requirement for Adnp in cortical neurogenesis and learning behavior

Sarah Larrigan, Lina Alegria Dizon-Mapula, Iris Lasker, David J. Picketts, Pierre A. Mattar

This study investigates the role of Adnp in cortical neurogenesis and learning behavior through allelic series analysis, finding that Adnp dosage affects cortical growth and learning, with similar phenotypes across different mutant models.

bioRxiv · Jun 11, 2026 · PreprintNeuroscience

The ChAHP chromatin remodelling complex regulates neurodevelopmental disorder risk genes to scale the production of neocortical layers

Samuel Clémot-Dupont, José Alex Lourenço Fernandes, Sarah Larrigan, Xiaoqi Sun, Suma Medisetti, Rory Stanley, Ziyad El Hankouri, Shrilaxmi V. Joshi, David J. Picketts, Karthik Shekhar, Pierre A. Mattar

The paper shows that the ChAHP complex regulates upper-layer neuron production and NDD risk genes during neocortical development through progenitor proliferation and gene regulation.

Proceedings of the National Academy of Sciences · Jan 14, 2025Peer-reviewedNeuroscience

Divergent phenotypes in germline versus conditional mutant mouse models of Sifrim-Hitz- Weiss Syndrome

Sarah Larrigan, Shrilaxmi V. Joshi, Pierre A. Mattar

The paper compares germline and conditional Chd4 mutations in mice to show divergent phenotypes in brain development and behavior.

Human Molecular Genetics · Sep 19, 2023Peer-reviewedNeuroscience