Pierre A. Mattar

This study investigates the role of the ChAHP complex in retinal development by analyzing Adnp and Chd4 knockouts, revealing shared and distinct functions in cell proliferation and fate.

This study identifies Foxp1 as a transcriptional regulator that coordinates early progenitor identity with neurogenic progression in the developing retina by activating early-stage genes and proneural factors while repressing late temporal factors.

This study identifies TCF4 as a downstream effector of PHF6 in neural stem cell regulation, showing its role in restricting self-renewal and rescuing BFLS phenotypes.

This study investigates the role of Adnp in cortical neurogenesis and learning behavior through allelic series analysis, finding that Adnp dosage affects cortical growth and learning, with similar phenotypes across different mutant models.

This study shows that Chd4 remodels chromatin to control retinal cell fate by repressing progenitor identity and promoting rod photoreceptor production, without affecting the competence windows for early vs. late cell-type production.

The paper shows that the ChAHP complex regulates upper-layer neuron production and NDD risk genes during neocortical development through progenitor proliferation and gene regulation.

This study shows Pten and Dscam regulate amacrine cell spacing through endocytic trafficking of cell adhesion and signaling molecules, with altered extracellular vesicles and Wnt signaling in Pten mutants.

The paper identifies self-renewing osteochondral stem cells in the postnatal skeleton and compares their transcriptomes across adult, fetal, mouse, and human samples.

The paper compares germline and conditional Chd4 mutations in mice to show divergent phenotypes in brain development and behavior.

This study shows that temporal identity factors can reprogram adult Muller glial cells and fibroblasts into neurons in mice, using scRNA-seq to validate the transcriptional changes.

GliaMorph quantifies Müller glial cell morphology across developmental and disease states, revealing structural changes and subcellular features in zebrafish and mouse models.

This study shows Ikzf1 and Ikzf4 regulate distinct cell fates in the mouse retina through different cis-regulatory elements and temporal expression patterns.

This study identifies Casz1's role in regulating temporal identity transitions in neural progenitors through interactions with the NuRD and polycomb repressor complexes during retinal neurogenesis.