Phosphorylation enables allosteric control of a viral condensate
Julia Acker, Xinyu Wang, Daniel Desirò, Tanushree Agarwal, Alice Colyer, Cyril Haller, Rob M. Scrutton, Lee Sherry, Kadi Liis Saar, Rosie Murray, Ksenia V. Fominykh, Sai Hou Chong, Jeremy D. Schmit, Antonio N. Calabrese, Tuomas P. J. Knowles, Alexander Borodavka
This study shows that phosphorylation enables distinct nucleation mechanisms for NSP5 condensate formation in rotaviruses, depending on strain-specific LLPS propensity.
bioRxiv · May 24, 2025 · PreprintBiophysics