Author

Alice Colyer

University of LeedsORCID 0000-0002-1880-1995Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:proteomics· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Approach:statistical model· 1

Frequent Co-Authors

Adnan SljokaiD· 1 shared Alexander BorodavkaiD· 1 shared Antonio N. CalabreseiD· 1 shared Cristina LentoiD· 1 shared Cyril HalleriD· 1 shared Daniel DesiròiD· 1 shared Derek J. WilsoniD· 1 shared Esther WolfiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

Adnan SljokaORCID

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2 papers

Recent·Most cited

Phosphorylation enables allosteric control of a viral condensate

Julia Acker, Xinyu Wang, Daniel Desirò, Tanushree Agarwal, Alice Colyer, Cyril Haller, Rob M. Scrutton, Lee Sherry, Kadi Liis Saar, Rosie Murray, Ksenia V. Fominykh, Sai Hou Chong, Jeremy D. Schmit, Antonio N. Calabrese, Tuomas P. J. Knowles, Alexander Borodavka

This study shows that phosphorylation enables distinct nucleation mechanisms for NSP5 condensate formation in rotaviruses, depending on strain-specific LLPS propensity.

bioRxiv · May 24, 2025 · PreprintBiophysics

Allostery links hACE2 binding, pan-variant neutralisation and helical extension in the SARS-CoV-2 Spike protein

Alice Colyer, Esther Wolf, Cristina Lento, Mart Ustav, Adnan Sljoka, Derek J. Wilson

This paper shows that the antibody ICO-hu104 neutralizes SARS-CoV-2 by causing allosteric changes in the HR1 domain, leading to destabilization of helices and impairing viral fusion.

bioRxiv · Jan 28, 2025 · PreprintBiochemistry