Author

Ruan Zhang

Cedars-Sinai Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Ambart E. CovarrubiasiD· 1 shared Anders Hayden BergiD· 1 shared Bongha ShiniD· 1 shared Jordan Mundell· 1 shared Madhusudhanarao KatikiiD· 1 shared Margareta Danuta PisarskaiD· 1 shared Michifumi YamashitaiD· 1 shared Peter S. HeegeriD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Ambart E. CovarrubiasORCID

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Author profile →

1 paper

Recent·Most cited

Butyrophilin 2A2 promotes T cell immunoregulation by enhancing CD45 phosphatase activity within the immune synapse

Shafat Ali, Anders Hayden Berg, Michifumi Yamashita, Ambart E. Covarrubias, Jordan Mundell, Pranali Nitin Shah, Ruan Zhang, Vincent Dupont, Bongha Shin, Shen Yang, Madhusudhanarao Katiki, Ramachandran Murali, Margareta Danuta Pisarska, Ravi Thadhani, Peter S. Heeger, , S. Ananth Karumanchi

This study identifies BTN2A2 as a CD45RO ligand that enhances CD45 phosphatase activity, promoting Treg expansion and reducing Th17 cells, thereby ameliorating autoimmunity in mice and humans.

Nature Communications · Jan 8, 2026Peer-reviewedImmunology