Cell BiologybioRxivPreprint
P-Rex1 Limits the Agonist-Induced Internalisation of GPCRs Independently of its Rac-GEF Activity
Martin J. Baker, Elizabeth Hampson, Priota Islam…·Heidi C. E. Welch
This paper shows P-Rex1 limits agonist-induced GPCR internalisation through its PDZ, DEP, and IP4P domains, independent of its Rac-GEF activity, by inhibiting phosphorylation and interacting with Grk2.
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