Author

Elpida Tsonou

AstraZeneca (United Kingdom)ORCID 0000-0002-2363-3391Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

David C. HornigoldiD· 2 shared Heidi C. E. WelchiD· 2 shared Adam T. McCormackiD· 1 shared Andrew J. MasseyiD· 1 shared Anna G. RobertsiD· 1 shared David A. BakeriD· 1 shared Elisa BenettiiD· 1 shared Elizabeth Hampson· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersPhysiology

David C. HornigoldORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Prex1 controls glucose homeostasis by limiting glucose uptake and mitochondrial metabolism in liver through GEF-independent regulation of Gpr21

Julia Y. Chu, Elpida Tsonou, Polly A. Machin, Kirsty MacLellan‐Gibson, Anna G. Roberts, Stephen A. Chetwynd, Adam T. McCormack, John C. Stephens, Elisa Benetti, Gemma K. Kinsella, David A. Baker, David C. Hornigold, Heidi C. E. Welch

This study shows Prex1 regulates glucose homeostasis by reducing glucose uptake and mitochondrial metabolism in the liver, independent of its catalytic activity, through Gpr21 inhibition.

bioRxiv · Apr 14, 2025 · PreprintPhysiology

P-Rex1 Limits the Agonist-Induced Internalisation of GPCRs Independently of its Rac-GEF Activity

Martin J. Baker, Elizabeth Hampson, Priota Islam, Ruben Pelaez Moral, Eve A. Maunders, Kirsti Hornigold, Elpida Tsonou, David C. Hornigold, Roderick E. Hubbard, Andrew J. Massey, Heidi C. E. Welch

This paper shows P-Rex1 limits agonist-induced GPCR internalisation through its PDZ, DEP, and IP4P domains, independent of its Rac-GEF activity, by inhibiting phosphorylation and interacting with Grk2.

bioRxiv · Apr 14, 2025 · PreprintCell Biology