Author

Andrew J. Massey

Vernalis (R&D) Limited (United Kingdom)ORCID 0000-0002-0276-2573Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

David C. HornigoldiD· 1 shared Elizabeth Hampson· 1 shared Elpida TsonouiD· 1 shared Eve A. MaundersiD· 1 shared Heidi C. E. WelchiD· 1 shared Kirsti Hornigold· 1 shared Martin J. BakeriD· 1 shared Priota IslamiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCell Biology

David C. HornigoldORCID

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1 paper

Recent·Most cited

P-Rex1 Limits the Agonist-Induced Internalisation of GPCRs Independently of its Rac-GEF Activity

Martin J. Baker, Elizabeth Hampson, Priota Islam, Ruben Pelaez Moral, Eve A. Maunders, Kirsti Hornigold, Elpida Tsonou, David C. Hornigold, Roderick E. Hubbard, Andrew J. Massey, Heidi C. E. Welch

This paper shows P-Rex1 limits agonist-induced GPCR internalisation through its PDZ, DEP, and IP4P domains, independent of its Rac-GEF activity, by inhibiting phosphorylation and interacting with Grk2.

bioRxiv · Apr 14, 2025 · PreprintCell Biology