P-Rex1 Limits the Agonist-Induced Internalisation of GPCRs Independently of its Rac-GEF Activity
Martin J. Baker, Elizabeth Hampson, Priota Islam, Ruben Pelaez Moral, Eve A. Maunders, Kirsti Hornigold, Elpida Tsonou, David C. Hornigold, Roderick E. Hubbard, Andrew J. Massey, Heidi C. E. Welch
This paper shows P-Rex1 limits agonist-induced GPCR internalisation through its PDZ, DEP, and IP4P domains, independent of its Rac-GEF activity, by inhibiting phosphorylation and interacting with Grk2.
bioRxiv · Apr 14, 2025 · PreprintCell Biology