Priota Islam

This paper shows P-Rex1 limits agonist-induced GPCR internalisation through its PDZ, DEP, and IP4P domains, independent of its Rac-GEF activity, by inhibiting phosphorylation and interacting with Grk2.

This study uses C. elegans models to show that eIF2D is essential for RAN translation in C9orf72 expansions, and its inhibition extends lifespan and reduces disease.

The paper identifies direct targets of the terminal selector UNC-3 in C. elegans motor neurons and shows that its function is temporally modular, with distinct roles in maintaining neuronal identity across life stages.

The paper identifies a terminal selector that prevents a Hox transcriptional switch to maintain motor neuron identity in C. elegans.