Elevating levels of the endocannabinoid 2-arachidonoylglycerol blunts opioid reward but not analgesia
Arlene Martínez-Rivera, Robert N. Fetcho, Lizzie Birmingham, Jin Xu, Ruirong Yang, Careen Foord, Diego Scala-Chávez, Narmin Mekawy, Kristen E. Pleil, Virginia M. Pickel, Conor M. Liston, Carlos M. Castorena, Joshua Levitz, Ying‐Xian Pan, Lisa A. Briand, , Francis S. Lee
This study shows that increasing 2-AG levels reduces opioid reward but not analgesia in mice, suggesting a potential therapeutic strategy for pain treatment.
Science Advances · Nov 29, 2024Peer-reviewedNeuroscience