Symmetry and force response of cohesin loop extrusion are determined by diffusion of its motor and anchor domains
Maxim I. Molodtsov, Georgii E. Pobegalov, Runze Sha, Oleg Dobrokhotov, Torahiko L. Higashi, Frank Uhlmann, Chris A. Brackley
This study shows cohesin extrudes DNA loops symmetrically or asymmetrically based on applied force, with loop extrusion controlled by stochastic switching of the motor domain and diffusive motion of the anchor domain.
bioRxiv · Jun 10, 2026 · PreprintBiophysics