Frank Uhlmann

The paper predicts a cohesin acetylation complex in budding yeast that interacts with nicked DNA and confirms its function through experiments.

This study identifies the N-gate as the primary DNA entry gate into the cohesin ring through biochemical and in vivo experiments in fission yeast.

This study shows cohesin extrudes DNA loops symmetrically or asymmetrically based on applied force, with loop extrusion controlled by stochastic switching of the motor domain and diffusive motion of the anchor domain.

This study investigates chromosome size determinants in fission yeast and finds that condensin levels, not cell or nuclear volume or mitosis duration, primarily influence chromosome dimensions.

This study identifies a novel feedback system regulating Cdk function through Spo12, a small disordered protein that inhibits PP2A, and shows its role in enhancing cell proliferation in fission yeast.

The paper quantifies progressive changes in chromosome shape during cell divisions and finds that an alternative loop capture model explains the observed arm length to width relationship better than the loop extrusion model.

This study reconstitutes sister chromatid cohesion in budding yeast, revealing two pathways for cohesin recruitment and a two-step mechanism for co-entrapment.

This study directly visualizes replisome-cohesin interactions and shows that replisomes pass through cohesin rings, establishing cohesion between sister chromatids.

The paper presents a telomere-to-telomere genome assembly of S. japonicus, revealing a previously unknown second centromere-like region and revising the genome size estimate.

This study shows that chromatin loops form through transcription-driven DNA-DNA capture rather than loop extrusion by cohesin.

The paper shows that dense Rap1 arrays block DNA loop extrusion by condensin in yeast, acting as contact insulators and affecting dicentric chromosome resolution.

This study uses cryo-EM and biochemical experiments to reveal the mechanism of DNA entry into the cohesin ring, showing how ATP binding and hydrolysis regulate the process.