Maxim I. Molodtsov

This study shows cohesin extrudes DNA loops symmetrically or asymmetrically based on applied force, with loop extrusion controlled by stochastic switching of the motor domain and diffusive motion of the anchor domain.

This study directly visualizes replisome-cohesin interactions and shows that replisomes pass through cohesin rings, establishing cohesion between sister chromatids.

This paper introduces SQUASSH, a convolutional neural network that fits structural models to fluorescence microscopy data to quantify variability across biological scales.

This paper introduces a new mechanism of DNA bending dissipation, bending friction, which explains slow DNA looping dynamics and is independent of ionic conditions.

The paper investigates how force-transducing molecular ensembles at microtubule tips regulate mitotic spindle size and bipolar organization in human cells.

This study shows that chromatin loops form through transcription-driven DNA-DNA capture rather than loop extrusion by cohesin.

This paper introduces SID, a computational method that extends light-field microscopy to enable high-speed volumetric Ca2+ imaging in scattering mammalian tissue.