Author

Torahiko L. Higashi

The Francis Crick Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Organism:yeast· 1

Frequent Co-Authors

Frank UhlmanniD· 3 shared Alessandro CostaiD· 1 shared Ambrosius P. SnijdersiD· 1 shared Andrea NansiD· 1 shared Chris A. BrackleyiD· 1 shared Francis J. O’ReillyiD· 1 shared George PapageorgiouiD· 1 shared Georgia WhittoniD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersMolecular Biology

Frank UhlmannORCID

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3 papers

Recent·Most cited

DNA entry into the cohesin ring through the kleisin N-gate

Karolina Gmurczyk, Torahiko L. Higashi, Georgia Whitton, Frank Uhlmann

This study identifies the N-gate as the primary DNA entry gate into the cohesin ring through biochemical and in vivo experiments in fission yeast.

bioRxiv · Aug 4, 2026 · PreprintMolecular Biology

Symmetry and force response of cohesin loop extrusion are determined by diffusion of its motor and anchor domains

Maxim I. Molodtsov, Georgii E. Pobegalov, Runze Sha, Oleg Dobrokhotov, Torahiko L. Higashi, Frank Uhlmann, Chris A. Brackley

This study shows cohesin extrudes DNA loops symmetrically or asymmetrically based on applied force, with loop extrusion controlled by stochastic switching of the motor domain and diffusive motion of the anchor domain.

bioRxiv · Jun 10, 2026 · PreprintBiophysics

A Structure-Based Mechanism for DNA Entry into the Cohesin Ring

Torahiko L. Higashi, Patrik Eickhoff, Joana S. Sousa, Julia Locke, Andrea Nans, Helen R. Flynn, Ambrosius P. Snijders, George Papageorgiou, Nicola O’Reilly, Zhuo Angel Chen, Francis J. O’Reilly, Juri Rappsilber, Alessandro Costa, Frank Uhlmann

This study uses cryo-EM and biochemical experiments to reveal the mechanism of DNA entry into the cohesin ring, showing how ATP binding and hydrolysis regulate the process.

Molecular Cell · Aug 4, 2020Peer-reviewedMolecular Biology