Targeting the TEA DNA binding Domain of TEAD with a Peptide Inhibitor TEAi Suppresses Oncogenic Transcription and Tumor Growth
Hui Xiong, Ruohui Han, Xiaohui Lin, Shian Wu, Lei Cao
This paper develops TEAi, a peptide inhibitor targeting TEAD's DNA-binding domain, which suppresses TEAD-YAP/TAZ-driven transcription and tumor growth.
bioRxiv · Aug 31, 2025 · PreprintCell Biology