Design of synthetic activators for programmable gene expression
Wei Chen, Ruopu Jiao, Brian Coventry, Xiangli Qu, Magnus S. Bauer, Long Tran, Tabitha Tcheau, Kejia Wu, Zihao Song, Nicole Roullier, Xinting Li, Cameron J. Glasscock, Isaac B. Hilton, David Baker
This study designs synthetic activators for programmable gene expression by engineering coactivator-binding proteins and demonstrates their enhanced transcriptional activation capabilities.
bioRxiv · Oct 20, 2026 · PreprintSynthetic Biology