Author

Xiangli Qu

University of WashingtonORCID 0000-0002-7556-7664Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:CRISPR screen· 1 Approach:deep learning· 1 Organism:human· 1 Assay:protein structure· 1

Frequent Co-Authors

Brian CoventryiD· 2 shared David A. BakeriD· 2 shared Long TraniD· 2 shared Magnus S. BaueriD· 2 shared Amir MotmaeniD· 1 shared Amrita Nallathambi· 1 shared Ana-Maria BratovianuiD· 1 shared André LieberiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersSynthetic Biology

Brian CoventryORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Design of synthetic activators for programmable gene expression

Wei Chen, Ruopu Jiao, Brian Coventry, Xiangli Qu, Magnus S. Bauer, Long Tran, Tabitha Tcheau, Kejia Wu, Zihao Song, Nicole Roullier, Xinting Li, Cameron J. Glasscock, Isaac B. Hilton, David Baker

This study designs synthetic activators for programmable gene expression by engineering coactivator-binding proteins and demonstrates their enhanced transcriptional activation capabilities.

bioRxiv · Oct 20, 2026 · PreprintSynthetic Biology

De novo design of miniprotein agonists and antagonists targeting G protein-coupled receptors

Edin Muratspahić, David Feldman, David E. Kim, Xiangli Qu, Ana-Maria Bratovianu, Paula Rivera-Sánchez, Jan Hendrik Voss, Emil Peter Thrane Hertz, Mads Jeppesen, Federica Dimitri, Kensuke Sakamoto, Amrita Nallathambi, Pia Peceli, Jianjun Cao, Brian P. Cary, , David A. Baker

This paper presents computational methods for designing GPCR-binding miniproteins and validates them through high-throughput screening, producing agonists and antagonists for multiple GPCRs.

bioRxiv · Mar 23, 2025 · PreprintBioengineering