Hydration Network Drives Activation and G Protein Selectivity in GPR174
Yingjun Dong, Kun Xi, Zhang Ya-zhi, Jian-Heng Xue, Dan-dan Shen, Shao-Kun Zang, Ruozhu Zhao, Hai Qi, Chunyou Mao, Wei-Wei Wang, Yan Zhang
This study identifies a hydration network in GPR174 that drives receptor activation and G protein selectivity through structural and functional analyses.
bioRxiv · Oct 6, 2025 · PreprintBiophysics