Kun Xi

This study designs high-fidelity CRISPR-Cas variants using a physics-driven approach combining molecular dynamics and protein language models, achieving significant improvements in fidelity with minimal experimental validation.

This study presents cryo-EM structures of the apelin receptor in various oligomeric states to elucidate the dynamic monomer-dimer transition and its role in signaling.

This study identifies a hydration network in GPR174 that drives receptor activation and G protein selectivity through structural and functional analyses.

This paper investigates how modifying PNA with s2U adjacent to Q residues enhances binding affinity and functional activity toward dsRNAs, demonstrating broader applicability in targeting structured RNA structures.

This paper introduces daPNAs, a programmable platform combining dbPNAs and asPNAs to target RNA junctions, demonstrating their use in inhibiting Dicer and regulating ribosomal frameshifting.

This study reveals the constitutive activity and dimerization mechanism of GPR156, explaining its role in auditory function through cryo-EM structures and functional analysis.