Author

Dan-Dan Shen

Sir Run Run Shaw Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:cryo-EM· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Research Focus:cell signaling & trafficking· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

Chunyou MaoiD· 3 shared Yan ZhangiD· 3 shared Kun XiiD· 2 shared Wei-Wei WangiD· 2 shared Bingpeng YaoiD· 1 shared Chao ZhangiD· 1 shared H. Eric XuiD· 1 shared Hai QiiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersBiophysics

Chunyou MaoORCID

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Author profile →

3 papers

Recent·Most cited

Dynamic Monomer-Dimer Transition in Ligand-induced Apelin Receptor Activation

Su‐Yu Ji, Wei-Wei Wang, Yixin Yang, Ping Xu, Jiangrong Zhang, Xinyue Zhao, Kun Xi, Shao‐Kun Zang, Dan-Dan Shen, Chunyou Mao, Qingya Shen, Yan Zhang

This study presents cryo-EM structures of the apelin receptor in various oligomeric states to elucidate the dynamic monomer-dimer transition and its role in signaling.

Nature Communications · Apr 3, 2026Peer-reviewedMolecular Biology

Hydration Network Drives Activation and G Protein Selectivity in GPR174

Yingjun Dong, Kun Xi, Zhang Ya-zhi, Jian-Heng Xue, Dan-dan Shen, Shao-Kun Zang, Ruozhu Zhao, Hai Qi, Chunyou Mao, Wei-Wei Wang, Yan Zhang

This study identifies a hydration network in GPR174 that drives receptor activation and G protein selectivity through structural and functional analyses.

bioRxiv · Oct 6, 2025 · PreprintBiophysics

Structural Basis of GPCR-G Protein Pre-coupling and Activation: Insights from CCR1-Gi Complex

Zhehua Shao, Yingjun Dong, Ruixin Jia, Qingya Shen, Bingpeng Yao, Xinheng He, Qingning Yuan, Dan-Dan Shen, Chunyou Mao, Chao Zhang, Zhihua Chen, H. Eric Xu, Songmin Ying, Yan Zhang, Wen Li

The paper solves the cryo-EM structure of CCR1-Gi complex in pre-coupled state, revealing molecular mechanism of GPCR-G protein activation and highlighting conserved pre-coupling in chemokine receptors.

bioRxiv · Nov 1, 2024 · PreprintBiophysics