Chunyou Mao

This study presents cryo-EM structures of the apelin receptor in various oligomeric states to elucidate the dynamic monomer-dimer transition and its role in signaling.

This study identifies a hydration network in GPR174 that drives receptor activation and G protein selectivity through structural and functional analyses.

The paper solves the cryo-EM structure of CCR1-Gi complex in pre-coupled state, revealing molecular mechanism of GPCR-G protein activation and highlighting conserved pre-coupling in chemokine receptors.

This study reveals the constitutive activity and dimerization mechanism of GPR156, explaining its role in auditory function through cryo-EM structures and functional analysis.

The paper identifies a splice variant of the GHRHR receptor that mediates constitutive signal bias towards β-arrestin recruitment, impacting downstream signaling pathways in prostate cancer cells.

The paper reports high-resolution structures of MC4R with agonists and reveals insights into ligand recognition and activation mechanisms.

The paper reports cryo-EM structures of LHCGR in different activation states, revealing a push and pull mechanism of receptor activation and the role of an allosteric agonist.

This study reports the structure of SARS-CoV-2 RdRp with and without Remdesivir, showing how the drug inhibits viral RNA replication by terminating chain elongation.

The paper presents cryo-EM structures of the GABAB receptor in inactive and active states, revealing structural changes and Gi1 coupling mechanisms.