Lifelong restriction of dietary valine has sex-specific benefits for health and lifespan in mice
Mariah F. Calubag, Ismail Ademi, Cara L. Green, Dulmalika N. H. Manchanayake, Hashan S. M. Jayarathne, Ryan N. Marshall, Sandra M. Le, Penelope Lialios, Lucia E. Breuer, Shoshana Yakar, Reji Babygirija, Michelle M. Sonsalla, Isaac Grunow, Chung-Yang Yeh, Yang Liu, , Dudley W. Lamming
This study shows that lifelong dietary valine restriction improves healthspan and extends lifespan in male mice but not females, with distinct molecular effects in different tissues.
Nature Aging · Jul 24, 2026Peer-reviewedPhysiology