Author

Sandra M. Le

University of Wisconsin–Madison

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Bailey A. KnopfiD· 2 shared Dudley W. LammingiD· 2 shared Isaac Grunow· 2 shared Ismail AdemiiD· 2 shared Mariah F. CalubagiD· 2 shared Michelle M. SonsallaiD· 2 shared Penelope Lialios· 2 shared Reji BabygirijaiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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2 shared papersPhysiology

Bailey A. KnopfORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Lifelong restriction of dietary valine has sex-specific benefits for health and lifespan in mice

Mariah F. Calubag, Ismail Ademi, Cara L. Green, Dulmalika N. H. Manchanayake, Hashan S. M. Jayarathne, Ryan N. Marshall, Sandra M. Le, Penelope Lialios, Lucia E. Breuer, Shoshana Yakar, Reji Babygirija, Michelle M. Sonsalla, Isaac Grunow, Chung-Yang Yeh, Yang Liu, , Dudley W. Lamming

This study shows that lifelong dietary valine restriction improves healthspan and extends lifespan in male mice but not females, with distinct molecular effects in different tissues.

Nature Aging · Jul 24, 2026Peer-reviewedPhysiology

Tissue-specific effects of dietary protein on cellular senescence are mediated by branched-chain amino acids

Mariah F. Calubag, Ismail Ademi, Isaac Grunow, Lucia Breuer, Reji Babygirija, Penelope Lialios, Sandra M. Le, Dennis M. Minton, Michelle M. Sonsalla, Julia A. Illiano, Bailey A. Knopf, Fan Xiao, Adam R. Konopka, David A. Harris, Dudley W. Lamming

This study shows that dietary BCAA restriction mitigates metabolic issues and cellular senescence in mice, with tissue-specific effects observed.

Aging Cell · Jul 28, 2025Peer-reviewedPhysiology

A human and mouse subpopulation of senescent β-cells induces pathologic dysfunction through targetable paracrine signaling

Kanako Iwasaki, Priscila Carapeto, Cristian Abarca, Francesko Hela, Stephanie Sanjines, Sebastian Pena, Sandra M. Le, Hui Pan, Christopher Cahill, Ayush D. Midha, Juliana Alcoforado Diniz, Dylan S. Baker, Sergii Domanskyi, Sara Espinoza, Alejandro Pena, , Cristina Aguayo‐Mazzucato

The paper identifies senescent β-cell subpopulations in humans and mice that induce pathologic dysfunction through paracrine signaling and shows JAK inhibitors can reverse this effect.

bioRxiv · May 7, 2025 · PreprintDevelopmental Biology