Phosphatidylserine and RhoB connect phosphatidylinositol 4-phosphate and phosphatidic acid metabolism at the plasma membrane
Shiying Huang, Yeun Ju Kim, Xiaofu Cao, Timothy W. Bumpus, Mira Sohn, Matthew Tyler Menold, Ryan S. Dale, Jin Joo Kang, Saori Uematsu, Shagun Gupta, Shu‐Bing Qian, Haiyuan Yu, Tamás Balla, Jeremy M. Baskin
The paper identifies a metabolic connection between PI4P and PA at the plasma membrane, showing how PI4P depletion increases PA levels through PS synthesis and RhoB activation.
bioRxiv · Sep 30, 2025 · PreprintCell Biology