Author

Xiaofu Cao

Cornell UniversityORCID 0000-0002-2417-5652Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Jeremy M. BaskiniD· 3 shared Abhishek ChatterjeeiD· 2 shared Rachel E. Kelemen· 2 shared Shiying HuangiD· 2 shared Artur Lazarian· 1 shared Delilah JeweliD· 1 shared Din-Chi ChiuiD· 1 shared Haiyuan YuiD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersCell Biology

Jeremy M. BaskinORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Phosphatidylserine and RhoB connect phosphatidylinositol 4-phosphate and phosphatidic acid metabolism at the plasma membrane

Shiying Huang, Yeun Ju Kim, Xiaofu Cao, Timothy W. Bumpus, Mira Sohn, Matthew Tyler Menold, Ryan S. Dale, Jin Joo Kang, Saori Uematsu, Shagun Gupta, Shu‐Bing Qian, Haiyuan Yu, Tamás Balla, Jeremy M. Baskin

The paper identifies a metabolic connection between PI4P and PA at the plasma membrane, showing how PI4P depletion increases PA levels through PS synthesis and RhoB activation.

bioRxiv · Sep 30, 2025 · PreprintCell Biology

Inhibition of SQSTM1/p62 oligomerization and Keap1 sequestration by the Cullin-3 adaptor SHKBP1

Lin Luan, Xiaofu Cao, Jeremy M. Baskin

This study identifies SHKBP1 as a regulator of p62 oligomerization and antioxidant response by preventing Keap1 sequestration into p62 bodies, independent of ubiquitination.

bioRxiv · Jan 21, 2025 · PreprintCell Biology

A phosphorylation-controlled switch confers cell cycle-dependent protein relocalization

Xiaofu Cao, Shiying Huang, Mateusz Maciej Wagner, Yuan‐Ting Cho, Din-Chi Chiu, Krista Minéia Wartchow, Artur Lazarian, Laura Beth McIntire, Marcus Bustamante Smolka, Jeremy M. Baskin

The paper develops a system for mitosis-specific protein recruitment to the plasma membrane using a phosphorylation-controlled switch, without exogenous triggers.

Nature Cell Biology · Aug 29, 2024Peer-reviewedCell Biology

Precise manipulation of site and stoichiometry of capsid modification enables optimization of functional adeno-associated virus conjugates

Sarah B. Erickson, Quan Thanh Pham, Xiaofu Cao, Jake Glicksman, Rachel E. Kelemen, Seyed Sadegh Shahraeini, Sebastian Bodkin, Zainab Kiyam, Abhishek Chatterjee

This study shows that precise control over the site and stoichiometry of capsid modification in AAV vectors improves retargeting efficiency and activity.

Bioconjugate Chemistry · Dec 16, 2023Peer-reviewedSynthetic Biology

Virus-assisted directed evolution of enhanced suppressor tRNAs in mammalian cells

Rachel E. Kelemen, Delilah Jewel, Rachel L. Huang, Zeyu Zhu, Xiaofu Cao, Muhammad Pasha, Jon S Anthony, Tim van Opijnen, Abhishek Chatterjee

This paper develops VADER, a virus-assisted directed evolution method for improving suppressor tRNAs in mammalian cells, resulting in more active and orthogonal tRNA mutants.

bioRxiv · Jan 21, 2022 · PreprintSynthetic Biology