Jin Joo Kang

Identification of human RNA Polymerase II interactors at early stages of transcription.

The paper identifies human RNA Polymerase II interactors at early transcription stages using biochemical purification and mass spectrometry, revealing new factors involved in PIC assembly and promoter-proximal pausing.

Phosphatidylserine and RhoB connect phosphatidylinositol 4-phosphate and phosphatidic acid metabolism at the plasma membrane

The paper identifies a metabolic connection between PI4P and PA at the plasma membrane, showing how PI4P depletion increases PA levels through PS synthesis and RhoB activation.

A multiscale functional map of somatic mutations in cancer integrating protein structure and network topology

This paper introduces NetFlow3D, a framework that integrates protein structure and interaction networks to identify significant mutation clusters and modules in cancer, revealing biological processes not found by traditional methods.

MAGMa: Your Comprehensive Tool for Differential Expression Analysis in Mass-Spectrometry Proteomic Data.

MAGMa is a tool for differential expression analysis in mass-spectrometry proteomic data, showing improved sensitivity and specificity in detecting true signals.

Structurally-informed human interactome reveals proteome-wide perturbations by disease mutations

The paper introduces PIONEER, a deep learning framework for predicting protein-protein interfaces, and shows disease mutations are enriched in these interfaces, identifying oncoPPIs linked to cancer survival and drug responses.

FMRP regulates mRNAs encoding distinct functions in the cell body and dendrites of CA1 pyramidal neurons

The paper identifies compartment-specific FMRP targets in CA1 pyramidal neurons and shows how FMRP regulates different mRNA functions in cell bodies and dendrites.