Tau Filaments from Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex (ALS/PDC) adopt the CTE Fold
Chao Qi, Bert M. Verheijen, Yasumasa Kokubo, Yang Shi, Stephan Tetter, Alexey G. Murzin, Asa Nakahara, Satoru Morimoto, Marc Vermulst, Ryogen Sasaki, Eleonora Aronica, YOSHIFUMI S. HIROKAWA, Kiyomitsu Oyanagi, Akiyoshi Kakita, Benjamin Falcon, , Michel Goedert
This study uses cryo-EM to show that tau filaments in ALS/PDC share the CTE fold, suggesting environmental causes for the disease.
bioRxiv · Apr 26, 2023 · PreprintNeuroscience