BLM-dependent Break-Induced Replication handles DSBs in transcribed chromatin upon impaired RNA:DNA hybrids dissolution.
S Cohen, Aude Guénolé, Aline Marnef, Thomas Clouaire, Nadine Puget, Vincent Rocher, Coline Arnould, Marion Aguirrebengoa, Matthieu Genais, Dipti Vinayak Vernekar, Raphaël Mourad, Valérie Borde, Gaëlle Legube
This study shows BLM promotes Homologous Recombination at DSBs in active chromatin but switches to Break-Induced Replication when R-loop dissolution is impaired, reducing cell viability.
bioRxiv · May 13, 2020 · PreprintMolecular Biology