Palmitate-induced mitochondrial damage restricts histone acetylation in CD8+ T cells to impair anti-tumor immunity.
Silvia Tiberti, Martina Romeo, Letizia Rumiano, Carina B. Nava Lauson, Ilir Sheraj, Carlotta Catozzi, Roberta Noberini, Davide Olivari, Tiziano Dallavilla, S Galie, Mattia Ballerini, Alessia Loffreda, Martin H. Schaefer, Tiziana Bonaldi, Luigi Nezi, , Teresa Manzo
This study shows that palmitate impairs CD8+ T cell function by damaging mitochondria and reducing histone acetylation, leading to weakened anti-tumor immunity.
bioRxiv · Jan 9, 2025 · PreprintImmunology