Tiziana Bonaldi

This paper shows that extending G1 phase in cancer cells creates a therapeutic window for epigenetic drugs, with LSD1 inhibition and CDK4/6 inhibition working synergistically to induce differentiation and improve survival in AML models.

This paper identifies S166 phosphorylation on LSD1 as a regulatory switch that controls gene activation, chromatin remodeling, and tumor microenvironment in non-hormonal cancer cells.

This study reveals that TCA cycle rewiring at implantation supports histone acetylation programming and pluripotency transitions in mouse embryos.

This study shows that palmitate impairs CD8+ T cell function by damaging mitochondria and reducing histone acetylation, leading to weakened anti-tumor immunity.

This study identifies metabolic and age-related epigenetic barriers in converting mouse fibroblasts to induced cardiomyocytes, showing that metabolic modulation enhances reprogramming efficiency.

This study shows that GTF2I dosage affects neuronal differentiation and social behavior in 7q11.23 neurodevelopmental disorders using patient-derived organoids and mouse models.

The paper detects and quantifies histone post-translational modifications (PTMs) in three Aspergillus species, revealing strain-specific variations in PTM abundance and novel PTMs.

This study investigates how 7q11.23 CNVs affect protein synthesis and neuronal excitability in neurodevelopmental disorders using patient-derived neurons and multi-omics approaches.

The paper identifies host proteins interacting with SARS-CoV-2 RNA ends, highlighting pseudouridine synthase PUS7 and post-transcriptional modifications in viral RNA structure and function.

The paper presents a high-quality human methyl-proteome dataset generated using hmSILAC and a machine learning tool, showing improved identification of methyl-peptides and novel histone methylation marks.

This study identifies PRMT1-mediated methylation of the Large Drosha Complex as critical for miRNA biogenesis by regulating pri-to-pre-miRNA processing.